Validation of an FBA model for Pichia pastoris in chemostat cultures
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Possibilistic validation of a constraint-based model under data scarcity: application to Pichia pastoris cultures
Constraint-based modelling allows building structured models of cells without accounting for intracellular kinetics. These models can be combined with experimental data to estimate the (pseudosteady) state or phenotype exhibited by cells at given conditions, standing out as a useful analytical tool. In this work, a simplified, constraint-based model of Pichia pastoris, a widely recognized platf...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2014
ISSN: 1752-0509
DOI: 10.1186/s12918-014-0142-y